PLK1 induces CDC25C activation and WEE1 degradation as well ... Cyclin E is recruited to the centrosome via its centrosome localization domain to promote entry into the S phase and facilitate ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Polo-like kinase 1 (PLK1) is a conserved ...

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Then we obtained the receptor domains of AURKA, AURKB, CCNA2, CCNE1, CCNE2, CDC7, CDC25A, CDC25B, CDK1, CHEK1, PLK1, PLK4, and TYMS from the PDB database, and modified the protein by deleting ligands ...

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Request permissions for this article. Department of Colorectal Surgery and Oncology and Department of Cell Biology, Center for Medical Research and Innovation in Digestive System TumorsMinistry of ...

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Furthermore, Cenpas formation upon TRIM37 depletion requires PLK4, as well as two parallel pathways relying respectively on Centrobin and PLK1. Overall, our work uncovers how TRIM37 prevents Cenpas ...

One of the proteins responsible for controlling the cell cycle is Polo-Like Kinase 1 (PLK1), but studying this protein is difficult. A common way to investigate a protein's effect is to delete the ...