Nature22d
Deregulation of kinase signaling and lymphoid development in EBF1-PDGFRB ALL leukemogenesis
The chimeric fusion oncogene early B-cell factor 1–platelet-derived growth factor receptor-β (EBF1-PDGFRB) is a recurrent lesion observed in Philadelphia-like B-acute lymphoblastic leukemia (B ...
ascopubs.org26d
Challenging Conventional Diagnostic Methods by Comprehensive Molecular Diagnostics: A Nationwide Prospective Comparison in Children With ALL
Treatment stratification in ALL includes diverse (cyto)genetic aberrations, requiring diverse tests to yield conclusive data. We optimized the diagnostic workflow to detect all relevant aberrations ...
EurekAlert!27d
Applications of molecular genetic testing in hematopoietic and lymphocytic neoplasms
PDGFRB, and FGFR1. Rapid molecular diagnostics are crucial, as imatinib-sensitive fusions lead to favorable outcomes. FISH and targeted sequencing facilitate precise identification and treatment ...
eLife1mon
Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish
a, Confocal projections of pericytes (TgBAC(pdgfrb:egfp) ncv22) and brain vasculature (Tg(kdrl:Hsa.HRAS-mCherry) s843) in sibling and pdgfrb uq30bh mutants at 7 dpf. a′, Zoomed section from a (dashed ...
eLife1mon
Vascular mural cells protect the adult brain from haemorrhage but do not control the blood-brain barrier in developing zebrafish
Organogenesis and Cancer Program, Peter MacCallum Cancer Centre, Melbourne, Australia Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia Institute for Molecular ...
ki.se1y
Atopic dermatitis – Research group Maria Bradley
Atopic dermatitis (AD) is an inflammatory skin disorder. The pathogenesis is a complex interaction between environmental factors and genetic predisposition, The overall aim is to improve the ...