Peroxisome proliferator-activated receptor-γ (PPAR-γ) is a ligand-dependent nuclear receptor that has a critical role in adipogenesis, glucose metabolism and placental function 1,2,3.

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Researchers at UC San Francisco found that female mice expressing only a maternal X chromosome experience faster brain aging and cognitive decline compared to those expressing both maternal and ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...

PPARs include three subtypes: PPAR-α, PPAR-β/δ, and PPAR-γ ... The potential mechanism might be the E3 ligase translocation in renal carcinoma on chromosome 8 (TRC8), also known as RNF139, which leads ...

Innate immunity activates the corresponding immune response relying on multiple pattern recognition receptors (PRRs) that includes pattern recognition receptors (PRRs), like NOD-like receptors (NLRs), ...

Objective To determine the expression of PPARs in human fibrotic skin and investigate the effects of IVA337, a pan PPAR agonist, in in vitro and in vivo models of fibrosis. Methods The antifibrotic ...

A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these ... 24 hours prior to being treated with 10 ng/mL interferon gamma ...

uhnresearch.ca Objectives We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of ...

Robciuc MR, Skrobuk P, Anisimov A, Olkkonen VM, Alitalo K, Eckel RH, Koistinen HA, Jauhiainen M, Ehnholm C. Angiopoietin-like 4 mediates PPAR delta effect on lipoprotein lipase-dependent fatty acid ...

Clinical Physiology provides diagnostic methods to detect and evaluate dysfunction of various organs and systems in the body such as the heart, peripheral vessels, lungs, kidneys, gastrointestinal ...