A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR ... with sequence-specific, DNA-binding TFs, and Mediator interacts with the RNAPII enzyme at ...

We measured OxLDL uptake in wild-type and PPAR-γ–deficient macrophages that had been treated with rosiglitazone. Although rosiglitazone treatment resulted in an increase in DiI-OxLDL binding to ...

Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to ...

When you purchase through links on our site, we may earn an affiliate commission. Here’s how it works. The best blogging sites make it simple and easy to set up a blog, so you can keep ...

One of the trends we saw in this month’s data, growth for news sites, was also reflected in Similarweb’s Digital 100 report on the fastest-growing websites and apps of 2024. For example ...

However, obesity and nutritional factors attenuate expression only of PPARγ2. Figure 2 Activation of PPAR γ. After ligand binding, PPAR γforms heterodimers with the receptor for 9 cis-retinoid (RXR) ...

dDepartment of Molecular Brain Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto 860-8556, Japan eLaboratory for Molecular Mechanisms of Brain Development, RIKEN Center for ...

Proteins have various interaction sites, one of which is the protein-ligand binding site, essential for molecular interactions and biochemical reactions. These sites enable proteins to bind with other ...

Furthermore, a second mutually exclusive exon residing in an intracellular loop containing the binding sites for Caβ and G-protein βγ subunits promotes the expression and synaptic localization of ...

After hours: February 19 at 6:41:40 PM EST Loading Chart for SITC ...

Objective To determine the expression of PPARs in human fibrotic skin and investigate the effects of IVA337, a pan PPAR agonist, in in vitro and in vivo models of fibrosis. Methods The antifibrotic ...