gut.bmj15d
Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD
PPARα is less expressed in the liver of patients with non-alcoholic fatty liver diseases (NAFLD). Several PPAR-targeting molecules, including dual agonists, are currently under investigation for NAFLD ...
WPRI 1223d
Hoth Therapeutics Announces Positive Findings on GDNF's Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved ...
BioSpace23d
Hoth Therapeutics Announces Positive Findings on GDNF’s Potential as a Game-Changer in Obesity Treatment and Reduced Fatty Liver Disease
Inhibition of Fat Cell Formation (Adipogenesis) – GDNF suppressed key genes involved in fat storage, including PPAR-γ, FASN, and SREBF1, while promoting fat oxidation pathways. Improved Insulin ...
Frontiers28d
Research progress on ferroptosis in Myelodysplastic syndromes
A set of six feature genes (SREBF1, PTPN6, PARP9, MAP3K11, MDM4, EZH2) demonstrated high accuracy in MDS diagnosis. These findings underscore the complex relationship between FRGs and MDS (Zhu et al., ...
eLife1mon
Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
A subset of these lipids (e.g. oleamide, desmosterol) serve as ligands for nuclear receptors PPAR and LXR, and activation of these receptors occurred specifically during hyperactive IFN signaling in ...
Frontiers1mon
The role of ubiquitination and deubiquitination in cancer lipid metabolism
PPARs are a family of ligand-activated nuclear transcription factors. PPARs include three subtypes: PPAR-α, PPAR-β/δ, and PPAR-γ, with PPAR-γ being the most extensively studied. It has been found that ...