Frontiers23d
Diacylglycerol Kinases in T Cell Tolerance and Effector Function
Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and ...
eLife24d
SIV-specific neutralizing antibody induction following selection of a PI3K drive-attenuated nef variant
Functional analyses revealed that this change attenuates the ability of Nef to stimulate PI3K/Akt/mTORC2 signalling. The authors propose that this improved induction of SIVmac239 nAb is reciprocal to ...
EurekAlert!1mon
New advances in targeted therapies for PIK3CA-mutated cancers
PIP3 recruits AKT to the cell membrane, where AKT is activated through phosphorylation by PDK1 at T308 and by mTORC2 at S473. Activated AKT phosphorylates TSC1/2 and relieves its inhibition ...
Frontiers2y
Dengue activates mTORC2 signaling to counteract apoptosis and maximize viral replication
The mechanistic target of rapamycin (mTOR) functions in two distinct complexes: mTORC1, and mTORC2. mTORC1 has been implicated in the pathogenesis of flaviviruses including dengue, where it ...
eLife9y
The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium
The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by the removal of PDK1 (PDPK1), but does not depend on the downstream kinases AKT and mTORC1. High resolution ...