WebMD15d
Mevalonate Kinase Deficiency
What Is Mevalonate Kinase Deficiency? Mevalonate kinase deficiency (MKD) is a disease that runs in families. A problem with your immune system causes attacks of fever and symptoms like swollen ...
Frontiers23d
Exercise and Glycemic Control: Focus on Redox Homeostasis and Redox-Sensitive Protein Signaling
glycogen synthase kinase 3; IRS-1/2, insulin receptor substrates 1 and 2; mTORC1/2, mechanistic target of rapamycin complex 1/2; PDK1, phosphoinositide-dependent kinase-1; PI3K, phosphatidylinositol-3 ...
EurekAlert!1mon
New advances in targeted therapies for PIK3CA-mutated cancers
glycogen synthase kinase 3β; mTORC1/2, mammalian target of rapamycin complex 1/2; PDK1, phosphoinositide-dependent kinase 1; PI3K, phosphoinositide 3-kinase; PIP2, phosphatidylinositol (4,5 ...
Frontiers1mon
Homoharringtonine: mechanisms, clinical applications and research progress
Janus kinase 1; XIAP, X-linked; Inhibitor of Apoptosis Protein; PARP,Poly (ADP-ribose) polymerase; Oct4, Octamer-binding transcription factor 4; Sox2, SRY-box transcription factor 2; Nanog, Nanog ...
eLife6y
Reciprocal regulation among TRPV1 channels and phosphoinositide 3-kinase in response to nerve growth factor
NGF activates phosphoinositide 3-kinase (PI3K), the enzyme that generates PI(3,4)P 2 and PIP 3, and PI3K activity is required for sensitization. One tantalizing hint came from the finding that the ...
eLife9y
The tumor suppressor PTEN and the PDK1 kinase regulate formation of the columnar neural epithelium
The Pten phenotype is mimicked by constitutive activation of PI3 kinase and is rescued by the removal of PDK1 (PDPK1), but does not depend on the downstream kinases AKT and mTORC1. High resolution ...