Results We showed that hypoxia enhanced the stemness of HCC cells and hepatocarcinogenesis through enhancing HIF-1α deSUMOylation by SENP1 and increasing stabilisation and transcriptional activity of ...

Fang et al. find that in cell line models of TNBC, STAMBPL1 promotes expression of the transcription factor HIF-1a and its downstream target VEGF, with the consequence of stimulating neo-angiogenesis ...

Cody Scanlan/The Register / USA TODAY NETWORK The Class 1A and 2A state basketball tournament fields are now set for Wells Fargo Arena in Des Moines. Action starts on Monday, March 10 with ...

In Class 1A, Mason Bechen scored 24 points, Cole Griffith 14 and Drew Ries 11 as eighth-ranked North Linn beat Hillcrest Academy, 67-43. The Lynx built a double-digit first-half lead and extended ...

PIP3 recruits AKT to the cell membrane, where AKT is activated through phosphorylation by PDK1 at T308 and by mTORC2 at S473. Activated AKT phosphorylates TSC1/2 and relieves its inhibition ...

Ace Austin piled up 32 points, 11 rebounds and 11 assists in Monday’s Class 1A semifinal win over R.C. Hatch. The Spring Garden star had one favorite part of her triple-double. “I don’t ...

The IAF is expected to operate around 350 LCAs (Mk-1, Mk-1A and Mk-2 variants) in the coming decade and beyond. (HT File) Defence minister Rajnath Singh ordered the setting up of the five-member ...

State finals will be held March 6-8 at The Alamodome in San Antonio. Last season's boys state champions were Jayton (1A), Lipan (2A), Hitchcock (3A), Oak Cliff Faith Academy (4A), Lancaster (4A ...

Editor’s note: Real Change endorsed Prop 1A; the views of the newsroom are independent from the organization. After a short but expensive campaign, Proposition 1A — the initiative that will implement ...

Cancer is a leading cause of human death worldwide, and the modulation of the metabolic properties of T cells employed in cancer immunotherapy holds great promise for combating cancer. As a crucial ...