Diacylglycerol kinases (DGKs) are a family of enzymes that regulate the relative levels of diacylglycerol (DAG) and phosphatidic acid (PA) in cells by phosphorylating DAG to produce PA. Both DAG and ...

Akt, protein kinase B; AS160, Akt substrate of 160 kDa; GLUT4, glucose transporter 4; GSK3, glycogen synthase kinase 3; IRS-1/2, insulin receptor substrates 1 and 2; mTORC1/2, mechanistic target of ...

PIP3 recruits AKT to the cell membrane, where AKT is activated through phosphorylation by PDK1 at T308 and by mTORC2 at S473. Activated AKT phosphorylates TSC1/2 and relieves its inhibition ...

Enzymes are molecular machines that carry out the chemical reactions that sustain all life, an ability that has captured the attention of scientists like me. Consider muscle movement. Your body ...

School of Engineering Sciences in Chemistry, Biotechnology and Health, Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, 10044 Stockholm, Sweden School of Engineering ...

Herein, we report that in various cancer cells upon oxygen deprivation, HIF-1 activation down-modulates LD catabolism mediated by adipose triglyceride lipase (ATGL), the key enzyme for intracellular ...

Instead, correct neural tube formation relies upon the ability of PTEN to remove phosphate groups from a target lipid, which is important for limiting the activity of an enzyme called PDK1. Unlimited ...