Congenital heart disease (CHD) is one of the most common birth defects, but the full extent of its genetic underpinnings has ...

During a Case-Based Roundtable® event, John N. Allan, MD, discussed how new regimens using BTK inhibitors and venetoclax ...

The attributes and endurance of the T cell responses following prime and boost doses are important measures of vaccine quality. Here authors show, by studying reactivation responses to a ...

Notch1 is expressed uniformly throughout the mouse endocardium during the initial stages of heart valve formation, yet it remains unclear how Notch signaling is activated specifically in the AVC ...

1Department of Medicine, Cedars-Sinai Medical Center, Cedars-Sinai Cancer Institute, Los Angeles, California. 2Department of Biomedical Sciences, Cedars-Sinai Medical Center, Cedars-Sinai Cancer ...

1The Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, New York. 2Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.

Cardiovascular diseases (CVDs) are experiencing a rapid surge and are widely recognized as the leading cause of mortality in the current aging society. Given the multifactorial etiology of CVDs, ...

Although γ-secretase cleavage of Notch1 is essential in developmental biology and is altered in many cancers, the processing of this cell-surface receptor is relatively understudied. Only one sequence ...