In spite of recent advances in the management of multiple myeloma, cure has been elusive, with efforts to improve long-term ...

Although the cause of multiple myeloma is not known, research shows that genetic changes in the DNA of a single plasma cell ...

Osteolytic bone disease is a frequent complication of multiple myeloma ... development of novel drugs for the management of lytic disease in myeloma. Currently, bisphosphonates are the mainstay ...

Computed tomography (CT) is a sensitive tool for detection of the bone-destructive effects in MM as it can detect small osteolytic lesions ... is a hallmark of multiple myeloma (MM), associated ...

25, 2025 — A bone marrow ... Disease in Multiple Myeloma Jan. 14, 2025 — A team of researchers has developed a new biomaterial with high potential in in the treatment of bone lesions or ...

Pim-2 kinase is overexpressed in multiple myeloma (MM) cells to enhance their ... in MM by multiple factors overproduced in MM bone lesions, and because Pim-2 acts as a negative regulator of ...

Multiple myeloma, an incurable type of bone marrow cancer, often develops unnoticed in the bone marrow over decades. In advanced stages, lesions form that can destroy the bone and spread to other ...

Purpose: Current treatment guidelines strongly support the use of antiresorptive therapy in patients with newly diagnosed multiple myeloma ... patients with existing lytic lesions, osteoporosis or ...

Study reveals multiple high-risk genetic changes predict worse multiple myeloma outcomes across all treatments.

Multiple myeloma is a type ... that grow and multiply uncontrollably in bone marrow. While genetic changes to the DNA are what may cause multiple myeloma, abnormal chromosomes may contribute ...