Objective: Newborns are highly susceptible to bacterial sepsis. Mannan-binding lectin (MBL), M-, L- and H-ficolin recognize microorganisms and activate the complement system via MBL-associated ...
A number of pathogens can initiate the mannan-binding lectin and alternative pathways of complement activation. The classical and alternative pathways of complement activation all tag antigens ...
Zaltenibart is the most proximal inhibitor of the alternative pathway. It blocks mannan-binding lectin-associated serine protease-3 (MASP-3), the key activator of the alternative pathway ...
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