MDM2, on the other hand ... AKT, protein kinase B; AURKA, aurora kinase A; FBXW7, F-Box and WD repeat domain containing 7; GSK-3β, glycogen synthase kinase 3 beta; MAX, Myc-associated factor ...

Zhang et al.’s study highlights the advantage of peptide-based, MDM2-dependent TPD over conventional domain inhibition in achieving a specific and complete functional blockade of p300, while also ...

We discovered that the E3 ubiquitin protein ligase MDM2 (murine double minute 2) dynamically regulates the protein stability of both HIF1α (hypoxia-inducible factor 1 alpha) and HIF2α ...

Consequently, MDM2 has been the subject of extensive research aimed at ... The estimation of the applicability domain (AD), which defines the chemical space where the developed QSAR model can reliably ...

Domain Expansion, also known as "Ryoiki Tenkai" in Japanese, is an advanced barrier technique introduced in Jujutsu Kaisen. To activate a Domain Expansion, the user has to initiate it using a ...

Here, we found that MAGE-C2 directly interacts with MDM2 through its conserved MHD domain to inhibit the activity of MDM2 on p53 ubiquitination. Furthermore, TRIM28 acts as an MAGE-C2 binding partner ...

Typically, after being produced within the body, p53 is quickly degraded when the N-terminal domain interacts with a protein called MDM2. This regular cycle of production and degradation holds p53 ...

Typically, after being produced within the body, p53 is quickly degraded when the N-terminal domain interacts with a protein called MDM2. This regular cycle of production and degradation holds p53 ...

2010). Considering that USP7 binds to MDM2 via the TRAF domain instead of the catalytic core domain, berberine may block the USP7-MDM2 binding via interacting with the TRAF domain. However, the ...

The numerous functions of p53 are regulated by murine double minute 2 (MDM2). MDM2 directly binds to and blocks the N-terminal transcriptional activation domain of p53, promotes export of p53 from the ...