Accumulation of fat molecules is detrimental to the cell. Researchers from the Yong Loo Lin School of Medicine, National ...

The function of lysosomes is tightly regulated by complex cellular signals, including calcium ions moving into and out of lysosomes. Scientists have known how lysosomes release their calcium since ...

The discovery of lysosomes led to many new questions. The most critical question was: what was the physiological function of this "bag" of enzymes? The Function of Lysosomes One of the definitive ...

The protein Spns1 helps transport fat molecules out of lysosomes, preventing harmful buildup and offering insights for rare ...

The Golgi apparatus functions as a molecular assembly line ... they are directed to their appropriate destinations — either lysosomes, storage vesicles, or the plasma membrane (Figure 2).

New research has made a breakthrough in understanding how our cells manage to stay healthy by recycling important fat ...

The humble lysosome, which carries out so many essential functions, appears to live a double life as a potential traitorous agent. "The study highlights the close interaction between lysosomal ...

Damaged lysosomes are repaired by a lipid-based signaling pathway ... who was not involved in the study. But the pathway might function differently in other cells, including neurons, so more work is ...

Breakthrough NUS discovery sheds light on cellular recycling mechanism and potential for treating rare diseases Singapore ...

2024). The primacy of endolysosomal dysfunction in neurons and microglia aligns with a recent report that, in AD, both ApoE and Aβ aggregate within the microglial lysosome, compromising its function ...