The function of lysosomes is tightly regulated by complex cellular signals, including calcium ions moving into and out of lysosomes. Scientists have known how lysosomes release their calcium since ...

The humble lysosome, which carries out so many essential functions, appears to live a double life as a potential traitorous agent. "The study highlights the close interaction between lysosomal ...

2024). The primacy of endolysosomal dysfunction in neurons and microglia aligns with a recent report that, in AD, both ApoE and Aβ aggregate within the microglial lysosome, compromising its function ...

Strengths: The implications for health, disease, and therapeutic discovery are considerable, given the central role of autophagy and lysosome-related pathways in regulating critical cellular processes ...

This article reviews recent research advances regarding the tethering processes, regulation, and function of MLCSs and their role in neurological diseases. Figure 1. Four types of physical ...

Understanding how MLRO functions could lead to new therapeutic ... More information: Xiaowen Ma et al, Perspectives of mitochondria-lysosome-related organelle in hepatocyte dedifferentiation ...

A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers ...

Visualizing cells after editing specific genes can help scientists learn new details about the function of those genes. But ...

A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers cellular inflammation and aging and is linked to Alzheimer's disease, ...

An adaptor protein, PLEKHM1, interacts with Rab7, LC3 proteins, HOPS–SNARE complexes, and GABARAP proteins to facilitate fusion between autophagosomes and lysosomes. It is still unclear how EPG5, ...