Comic Book Movie26d
THE FANTASTIC FOUR: FIRST STEPS Concept Art Reveals First Look At Julia Garner's Silver Surfer & [SPOILER]
If this design does end up being true to what we see on the screen, it seems Shalla is going to look quite a bit like the Norrin Radd version of the space-faring hero (they've ditched her comic ...
bleedingcool28d
Marvel Confirms Death Of The Silver Surfer by Greg Pak & Sumit Kumar
"Written by Greg Pak (Planet Hulk, Darth Vader) and drawn by Sumit Kumar (Web of Spider-Verse, Spider-Man: Black Suit & Blood), the five-issue limited series promises a tragic fate for Norrin Radd ...
eLife4y
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling
Analysis of Wnt/β-catenin signaling in response to Wnt3a versus a ‘surrogate agonist’ that cross-links Fzd to LRP6, revealed identical structure-activity relationships. Thus, canonical Wnt/β-catenin ...
eLife5y
Tailored tetravalent antibodies potently and specifically activate Wnt/Frizzled pathways in cells, organoids and mice
Secreted Wnt proteins regulate development and adult tissue homeostasis by binding and activating cell-surface Frizzled receptors and co-receptors including LRP5/6. The hydrophobicity of Wnt proteins ...
Frontiers6y
LRP6 Knockdown Ameliorates Insulin Resistance via Modulation of Autophagy by Regulating GSK3β Signaling in Human LO2 Hepatocytes
Inhibition of the PI3K/AKT/mTOR signaling pathway induces autophagy activation. Additionally, depletion of LRP6 has been shown to increase insulin sensitivity but its mechanism is still not clear. We ...