For kids with extremely rare diseases, this promising technology provides a lifeline | Opinion
Genetically targeted technologies are built on Nobel Prize-winning science. They represent a scientific “quantum leap” that ...
eLife5y
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
Mitophagy, the selective removal of damaged mitochondria, is thought to be critical to maintain neuronal homeostasis. Mutations of proteins in the pathway cause neurodegenerative diseases, suggesting ...
eLife10y
Non-catalytic motor domains enable processive movement and functional diversification of the kinesin-14 Kar3
Motor proteins of the conserved kinesin-14 family have important roles in mitotic spindle organization and chromosome segregation. Previous studies have indicated that kinesin-14 motors are ...