The Apothecary Diaries defies the typical gender norms a male lead would portray in a history setting as Jinshi's character isn't limited to either spectrum.

Readers who enjoy an overpowered female protagonist in isekai manga should give the following examples a shot.

Kill the Villainess offers a twist on the isekai genre by featuring a heroine who wants to escape her new world via any means necessary.

Isekai anime love their MMORPGs. Here are great series set in games or fantasy worlds heavily inspired by RPGs.