Patients with loss-of-function mutations in IL10 or IL10 receptor (IL10R) genes develop severe, medical-refractory, infantile-onset inflammatory bowel disease (IBD). We have previously reported ...

Over the past few decades, the prevalence of chronic inflammatory and metabolic diseases has risen sharply, coinciding with significant environmental and lifestyle changes. While genetics play a role, ...

The genetic basis of most traits is highly polygenic and dominated by non-coding alleles. It is widely assumed that such alleles exert small regulatory effects on the expression of cis-linked genes.

Lactate, the end product of glycolysis, efficiently functions as the carbon source, signaling molecules and immune regulators. Lactylation, being regulated by lactate, has recently been confirmed as a ...

CD4 Th2 effector cells contribute to immune responses to helminths and allergens. There exists little information on Th2 cell heterogeneity and clonal distribution between organs. In this manuscript, ...