PARP7 is a mono-ADP-ribosyl transferase (mono-ART) which has recently gained attention due to its emerging role as a negative ...

Cells contain a DNA sensor called cGAS, which alerts the immune system to viral and bacterial infections, cell death, and cancer-related transformations. A research team led by Ikerbasque Research ...

A research led by Sergio P. Acebrón, Researcher Ikerbasque at the UPV/EHU, develops a key tool to visualize the immune response to abnormal DNA, opening new avenues for the treatment of diseases.

Our cells harbor a DNA detector termed cGAS to inform the immune system of viral and bacterial infections, cell death, as ...

Activated STING translocates to the Golgi apparatus, where it activates TBK1, leading to the phosphorylation of both STING and IRF3. Phosphorylated IRF3 dimerizes and induces the transcription of ...

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China Center for Translational Medicine, The ...

In this study, we reported that IRF3 can negatively regulate TRIF-mediated NF-κB signaling pathway. Overexpression of IRF3 can inhibit TRIF-mediated NF-κB signaling pathway. However, knockdown of IRF3 ...

MAVS forms large prion-like polymers that activate the cytosolic kinases IKK and TBK1, which in turn activate NF-κB and IRF3, respectively, to induce interferons. Here we show that MAVS polymers ...