eLife15d
Single-cell profiling reveals the intratumor heterogeneity and immunosuppressive microenvironment in cervical adenocarcinoma
We performed single-cell RNA sequencing on 11 samples of ADC tumor tissues, with other 4 SCC samples served as controls. The immunochemistry and multiplexed immunofluorescence were conducted to ...
Healthline23d
Understanding the Genetics of Multiple Sclerosis
Multiple sclerosis isn’t inherited, but having a family member with the disease can increase your chance of having the condition. While genetics influences your risk, environmental factors also ...
Cancer Research1mon
Abstract PR008: CD4+ T cell rest and activation is enabled by centralized control of state specific regulatory genes
We performed CRISPR screens in multiple primary human CD4+ T cell contexts to identify regulators that control expression of IL2RA, which is a canonical marker of T cell activation in pro-inflammatory ...
ki.se1y
Atopic dermatitis – Research group Maria Bradley
Atopic dermatitis (AD) is an inflammatory skin disorder. The pathogenesis is a complex interaction between environmental factors and genetic predisposition, The overall aim is to improve the ...
eLife3y
Robust T cell activation requires an eIF3-driven burst in T cell receptor translation
The work addresses the role of translation initiation in the early induction of specific genes during T cell activation. It primarily uses the Jurkat T cell line and demonstrates that the translation ...
Frontiers3y
BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the ...