The IDH enzyme catalyzes the oxidative carboxylation of isocitrate to α-ketoglutarate in the citric acid cycle, producing NADPH. Cancer-associated mutations in IDH1 and IDH2 result in the replacement ...

Second, DAF-12 downregulates IDH-1, another enzyme involved in NADPH production in the cytosol. Thus, the developmental switch (reproductive to dauer) is directly connected to the metabolic flux ...

Expression of NADPH oxidase component protein was detected by means of immunoblotting, and the affected genes were sequenced to identify causal mutations. Patients with chronic granulomatous ...

Please provide your email address to receive an email when new articles are posted on . Low-grade glioma is a historically challenging cancer to treat, with some patients succumbing to the disease ...