While hERG channel is notoriously regarded as an off-target due to drug-induced cardiotoxicity, its therapeutic potential as a drug target remains largely unexplored. Methods: This study investigated ...

Many drugs from different chemical classes and therapeutic areas have been shown to inhibit currents mediated via the hERG-coded ion channel, which is strongly correlated to a risk of inducing TdP.

Jennifer Love Hewitt’s hindsight is 20/20. The “Ghost Whisperer” actress reflected on being sexualized as a teen and having “grown men” make jokes about her breasts during her appearance ...