Hosted on MSN18d
Viral protein Nef enables a step toward off-the-shelf CAR T cell therapy for cancer
It worked in two ways: First, it reduced a protein called HLA-I on the surface of the CAR T cells. HLA-I normally serves as a red flag to the immune system, signaling that something is wrong and ...
Nature9mon
Heat shock proteins, HLA-DR and rheumatoid arthritis
Rather, HSP73 promiscuously binds protein in certain detergent lysates ... showed that the nonspecific association of HSP73 with all HLA-DR alleles was completely negated in Triton-X100 and ...
Hosted on MSN6mon
Scientists Have Finally Identified Where Gluten Intolerance Begins
Around 90 percent of people diagnosed with the condition carry a pair of genes that encode for a protein called HLA-DQ2.5. Of the remaining 10 percent, most have a similar protein called HLA-DQ8.
eLife1d
Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape
Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.
GEN16d
Making Strides Toward Off-the-Shelf CAR T Cell Therapy for Cancer
A new advance may make it possible to use off-the-shelf CAR T cells provided by healthy donors. The new approach studied in mice equipped CAR T cells with the viral protein Nef.
Medscape16d
Roles and Mechanism of Natural Killer Cells in Clinical and Experimental Transplantation
UL16-binding protein. CD94/ NKG2 (KLR) C-type lectin-like NKC (12p12.3-13.2) HLA class Ib (-E) NKC/Ly 49 NKG2D (KLRK1) C-type lectin-like NKC MIC and MHC class I-like NKG2D NCR Immunoglobulin ...