"We were delighted to discover not only important details about the mechanisms of HBV gene regulation, but also a promising ...

oral TLR7 agonist RG7854 and HBV core protein allosteric modulator RG7907. Dicerna is retaining an option to co-fund pivotal development of the product globally, which would entitle the company to ...

Median HBV DNA at baseline in these eight patients ... Core promoter, precore and core regions. The core protein was found to be mutated in five of the eight patients in their samples analyzed ...

To address this, new antivirals targeting different components of the HBV molecular machinery are being developed. Here we investigated the hepatitis B core protein (HBc) that forms the viral capsids ...

In this paper, the authors present an interesting strategy to interfere with the HBV life cycle: the preparation of geranyl and peptides' dimers that could impede the correct assembly of hepatitis B ...

HBV replication and life-cycle in hepatocytes ... Subsequently, the pgRNA is encapsidated by viral core and polymerase protein, and reverse transcribed into new viral rcDNA. The DNA-containing virus ...

HBV-specific CD8 + T cells with different target specificities (HBV core epitope vs HBV polymerase (pol ... Checkpoint inhibition (in vitro blockade with anti-programmed cell death protein 1 ...

Supercomputer simulations have revealed how changes in the shape of the HIV-1 capsid protein may help the virus squeeze its ...

or HBV core antibody (anti-HBc). The most common cause of HBVr is prolonged immunosuppression due to medications, particularly B-cell depleting agents like rituximab, or disease. HBsAg-positivity ...

Future Virology. 2008;3(3):253-264. HBV budding is driven by the intrinsic property of the S-protein to form particles at the cytoplasmic side of the ER, even in the absence of mature nucleocapsids.

From raw eggs to protein shakes, those hoping to expand their brawn are often encouraged to ingest vast quantities of protein. But how much is really necessary and what's the best way to consume it?

You don’t need to give up steaks entirely. But mounting evidence shows that a diet that incorporates more plant-based protein has a surprisingly large number of benefits for your health.