eLife13d
Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression
Mammalian genomes are organized by multi-level folding, yet how this organization contributes to cell type-specific transcription remain unclear. We uncovered that the nuclear protein SATB1 ...
Frontiers10mon
Activation of GABA type A receptor is involved in the anti-insomnia effect of Huanglian Wendan Decoction
Human GABRA1 and GABRB3 were cloned into pEG BacMam plasmids, respectively; a plasmid expressing human GABRG2 from the CMV promoter and EGFP from the EF1a promoter was constructed to ensure the ...
eLife10y
The transcription factor Pitx2 positions the embryonic axis and regulates twinning
Embryonic polarity of invertebrates, amphibians and fish is specified largely by maternal determinants, which fixes cell fates early in development. In contrast, amniote embryos remain plastic and can ...