Major criticisms: (1) Both FOXO1 and GRHL3 have been previously described as tumor suppressors, with reports of FOXO1 inhibiting tumor angiogenesis. Therefore, this work describes an apparently ...

Type 1 diabetes occurs when the immune system attacks pancreatic beta cells. Type 2 diabetes happens when the body cannot use insulin effectively. The two types differ in symptoms, causes ...

Here, we demonstrate that induced endothelial-specific depletion of the transcription factor Forkhead Box O1 (FoxO1) in male mice led to increased vascular density in adipose tissue. Upon high-fat ...