Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated ... cell growth, prevention of apoptosis, tumor invasion and neo-angiogenesis. Sorafenib is an oral multikinase ...

Further determination of the pathways involved in cell proliferation/apoptosis demonstrated a marked increase in the phosphorylation of ERK-1/2 in the colon of Cl-1Tg versus WT mice (figure 2D).

Conclusion c-MET/ERK/p21/PKM2 cascade and VEGFR2-induced angiogenesis are ... As cabozantinib induces HCC cell apoptosis, it is possible that cabozantinib treatment triggers the release of liver ...

Furin is identified as the key enzyme responsible for cleaving the apelin precursor. Inhibiting this cleavage could serve as ...

Apoptosis occurs in a wide range of human diseases. In animal models of virus-induced disease, apoptosis correlates with viral titre and can be found in areas targeted by viral infection, which ...

CIRBP Family, Tumors, Molecular Mechanisms, RNA-Binding Proteins, Cellular Stress Share and Cite: Cai, Y. , Wang, T. and Zhan ...

Cataclysm:Dark Days Ahead and the Ultimate Cataclysm tileset is the result of contributions from volunteers under the Creative Commons Attribution ShareAlike 3.0 license. The code and content of the ...

Additionally, it explores the underlying mechanisms by which these compounds modulate diverse signaling pathways associated with apoptosis, cell proliferation, tumor angiogenesis, invasion, metastasis ...

It is enriched in several types of cancer and contributes to carcinogenesis in various ways, including inactivation of the tumor suppressor p53, deregulation of apoptosis, induction of ...

In addition, the accumulation of abnormally processed CFTR in the endoplasmic reticulum results in unfolded protein responses that trigger ‘cell stress’ and apoptosis leading to dysregulation of the ...

Objectives Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since ...