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Autophagy-dependent changes in alternative splicing bias translation toward inflammation in senescent cells.
In this issue of Developmental Cell, Kim et al. identify that altered autophagy and SFPQ-dependent EIF4H splicing during senescence redirects translation to promote inflammation, informing therapeutic ...
eLife8y
Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1
mRNA is cotranscrptionally processed and packaged into messenger ribonucleoprotein particles (mRNPs) in the nucleus. Prior to export through the nuclear pore, mRNPs undergo several obligatory ...