By transiently blocking the heartbeat of E9.5 mouse embryos, we found that Notch activation in the arterial endothelium was dependent on its ligand Dll4, whereas the reduced expression of Dll4 in the ...

Department of Physiology, State Key Laboratory of Common Mechanism Research for Major Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Basic Medical Sciences and School of Basic Medicine, ...

The stock is up significantly so far in 2025 due to it reporting 2024 results and its anticipated top-line Phase 2/3 data readout for COMPANION-002, which is evaluating tovecimig (CTX-009, a DLL4 ...

Top-line Phase 2/3 data readout for COMPANION-002, evaluating tovecimig (CTX-009 - a DLL4 x VEGF-A bispecific antibody) in patients with biliary tract cancer (BTC), is on track for the end of the ...

The BTC market is small and competitive, with existing approved therapies, posing a risk despite tovecimig's unique DLL4+ targeting. Recent stock surge due to CTX-471 trial announcement ...

CD7+ CD5 - Lymphoid Progenitor Cell (LPC) differentiated from HSC evaluation on Day 21. DLL4 and VCAM1 were used as a supportive environment to drive differentiation to NK cell lineage.

1 College of Food and Bioengineering, Zhengzhou University of Light Industry, Zhengzhou, China 2 College of Food Science and Engineering, National Engineering Research Center of Wheat and Corn Further ...

Here, we show that the muscle fiber maintains a continuum of quiescent states, through a gradient of Notch ligand, Dll4, produced by the fiber and captured by QSCs. The abundance of Dll4 captured by ...

Additionally, since Delta-like ligand 4 (Dll4)-activated Notch signaling is a major modulator of angiogenesis, anti-Dll4 agents are being investigated to reduce vascularization of the tumor. Notch ...