With Eli Tomac's retirement, no 450 rider entered this week has scored more than one victory in Detroit, Michigan.

Local members of 4-H clubs entered everything from poultry to photography in the McLeod County Fair, earning many ribbons. The following are the Grand Champions and Reserve Champions respectively ...

A former Northwest student could face life in prison after being arrested and charged with sodomy or attempted sodomy of the ...

Cooper Webb is the defending Tampa winner. The four favorites to win the championship all finished in the top five.

Little Nightmares 3 is set to arrive later this year, following a delay. As such, there's still a lot to learn about the upcoming indie horror game and how it plans to build on the foundations the ...

But it does – and the Tesla Model 3 is the best known. It is, famously, a fully electric car – Tesla doesn’t do petrols, diesels or even hybrids – and it’s the US brand’s smallest and ...

Cullin-RING ligases (CRLs) are the largest class of E3 ubiquitin ligases regulating the stability and subsequent activity of a large number of important proteins responsible for the development and ...

Body Dimensions 156.1 x 75.6 x 8.3 mm (6.15 x 2.98 x 0.33 in) ...

was identified to trigger the ubiquitination and proteasome-mediated degradation of receptor interacting protein kinase 3 (RIPK3) and inhibit necroptosis (21). In summary, poxviruses encode PRANC ...

Unexpectedly, A3G degradation was also mediated by a Vif- and cullin-ring-independent pathway, which was effectively counteracted by USP49. Furthermore, clinical data suggested that USP49 is ...