This poster introduces the background of Ubiquitins, applications of Ubiquitins in research, and featured active Ubiquitins ...

(7−11) The heterobifunctional molecule in a PROTAC must have two functional domains that interact with the two different proteins and bring them together to induce the PPI. In contrast, molecular ...

These findings offer a structural dynamic perspective on ligand-induced protein degradation, providing insights to guide future PROTAC design endeavors. Assembling these stable CRBN-dBETx-BRD4 BD1 ...

Launched on 12/08/2014, the iShares MSCI ACWI Low Carbon Target ETF (CRBN) is a smart beta exchange traded fund offering broad exposure to the World ETFs category of the market. What Are Smart ...

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Rd, Shanghai 201203, China University of Chinese Academy of Sciences, No. 19A ...

However, after investigating Corbion (AMS:CRBN), we don't think it's current trends fit the mold of a multi-bagger. If you haven't worked with ROCE before, it measures the 'return' (pre-tax profit) a ...

Alfa Chemistry’s library includes many different PROTAC scaffolds needed to make these advanced bi-functional molecules. These include E3 ligase ligands such as CRBN and VHL, and linkers which act as ...

In order to optimally deploy IMiDs and their newer derivates CRBN E3 ligase modulators (CELMoDs ®) into future myeloma therapeutic regimens, it is imperative to understand the mechanisms behind the ...

We had previously demonstrated that cereblon (CRBN) is the target of thalidomide embryopathy and acts as a substrate receptor for the E3 ubiquitin ligase complex, Cullin-Ring ligase 4 (CRL4 CRBN) in ...