Scientists identified 195 genetic risk loci across 42 female reproductive health conditions, revealing shared genetic ...

Bardet-Biedl syndrome (BBS) is a ciliopathy that leads to progressive blindness due to degeneration of cone photoreceptors, but the mechanisms behind this are not well understood. The syndrome is ...

Erratum: Elective Discontinuation of Larotrectinib in Pediatric Patients With TRK Fusion Sarcomas and Related Mesenchymal Tumors Patients who were 20 years or older, diagnosed in 2013-2019 with breast ...

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it caused arrest at the G1 phase via the ATM/Chk2 pathway. This was accompanied by downregulation of key cell cycle proteins such as CDK2, Cyclin A2, CDK4/6, and Cyclin D1/E1 complexes.

A large, blood-based profiling study accurately identified clonal hematopoiesis (CH) variants, effectively decreasing clinical false positives missed by other plasma only approaches The study ...

WATERTOWN, Mass., Feb. 05, 2025 (GLOBE NEWSWIRE) -- Acrivon Therapeutics, Inc. (“Acrivon” or “Acrivon Therapeutics”) (Nasdaq: ACRV), a clinical stage precision medicine company utilizing its Acrivon ...

IBC specifically inhibits CHK2 to prevent DNA repair. The combined use of BKC and IBC enhances DNA damage to a level that triggers cancer cell death. IBC and BKC extend survival and induce replication ...

Two broadly known characteristics of germ cells in many organisms are their development as a ‘cyst’ of interconnected cells and their high sensitivity to DNA damage. Here we provide evidence that in ...