The canonical chemokine receptor CXCR4 and atypical receptor ACKR3 both respond to CXCL12 but induce different effector responses to regulate cell migration. While CXCR4 couples to G proteins and ...
A team of researchers from the Department of Biological Sciences and Bioengineering at the Indian Institute of Technology, Kanpur, have successfully visualised the atomic structure of CXCR2, a key ...
This important study provides compelling evidence that CCL28 plays a crucial role in regulating neutrophil function and host defense during mucosal infections, with CCL28 deficiency leading to greater ...
CXCR2, C-X-C motif chemokine receptor 2; CXCR4, C-X-C motif chemokine receptor 4; DAMPs, Damage associated molecular patterns; HIF1α, Hypoxia inducible factor 1 subunit alpha; ICAM1, Intercellular ...
The chemokine receptor CXCR4 and its ligand CXCL12 play an important homeostatic function by mediating the homing of progenitor cells in the bone marrow and regulating their mobilization into ...
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