eLife1mon
PRDM16 functions as a co-repressor in the BMP pathway to suppress neural stem cell proliferation
To understand how BMP signaling and PRDM16 suppress cell proliferation, we aimed to determine the transcriptional targets of SMAD4 and pSMAD1/5/8 in cells with and without BMP4. We first applied ...
Frontiers3y
Bone Morphogenetic Protein 4 Alleviates DSS-Induced Ulcerative Colitis Through Activating Intestinal Stem Cell by Target ID3
We also found that during this renewing period, SMAD4 and bone morphogenetic protein 4 (BMP4) expression were significantly upregulated. An extra BMP4 treatment could preserve the Lgr5 + ISCs and the ...
Frontiers3y
BMP4 Moderates Glycolysis and Regulates Activation and Interferon-Gamma Production in CD4+ T Cells
BMP4 is a key growth factor well known in promoting bone regeneration and has been reported to be able to regulate T cell development in the thymus. Here, we showed that BMP4 downregulates the ...
eLife6y
Hedgehog signaling patterns the oral-aboral axis of the mandibular arch
Using unbiased single-cell RNA-seq analysis followed by in situ analysis of gene expression profiles, we show that Shh and Bmp4 signaling pathways are activated in a complementary pattern along the ...