The phosphotyrosine-binding (PTB) domain of Numb, a protein involved in asymmetric cell division, has recently been shown to bind to the adapter protein Lnx through an LDNPAY sequence, to the Numb ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. TAR DNA-binding protein 43 (TDP-43) is a nuclear protein accumulating in intraneuronal ...

2004; Jundt et al., 2004). Such data introduce a new ubiquitin ligase, favorable for MM treatment. Ubiquitin-like protein Neural-precursor-cell-expressed-developmentally-down-regulated-8 (NEDD8) has a ...

People with diabetes should eat as much protein as people who don't have diabetes. In a healthy diet, roughly 10% to 35% of your daily calories should come from protein. Protein itself does not have ...

Apolipoprotein E (ApoE) is a key genetic risk factor in the complex landscape of Alzheimer’s disease (AD), especially in its late-onset sporadic form. Genetic variation in the ApoE gene is a ...

It holds that amyloid proteins prompt a cascade of biochemical changes in the brain that cause dementia. The supremacy of that hypothesis has exerted enormous pressure toward scientific conformity.