Multiple signaling pathways are engaged by the type I and II IFN receptors, but their specific roles and possible coordination in the generation of IFN-mediated biological responses remain unknown. We ...

Consistent with previously published work suggesting that S6K is the principal downstream signal affected ... in which rapamycin treatment resulted in a dramatic inhibition of phosphorylation of S6 ...

Po opublikowaniu filmiku z napaści na drodze zatrzymany został Jacek Z., sołtys Kątów Rybackich na Mierzei Wiślanej. "W pełni potępiamy zachowania, których granice zostały przekroczone" - skomentował ...

Methods and results Target validation assays showed significant expression of phosphorylated ribosomal protein S6 (pS6), a downstream mediator of ... B and dendritic cells (DCs) and AKT activation ...

The Audi S6 Avant TDI takes to the road with a high-torque V6 TDI engine, offering customers in Europe ideal performance for long-distance driving. The S sports suspension with damper control, dynamic ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. m 6 A RNA modification has been linked to ...

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Despite major interest in this pathway for cancer drug discovery, no drugs have yet been approved that act specifically against PI3K or its downstream regulator, AKT. However, several drugs that ...

The deficiency of these nutrients upregulates Wingless in a closely located tissue, body wall muscle. Muscle-derived Wingless activates Akt in the neurons through the receptor tyrosine kinase Ror, ...

As a key protein in PI3K/Akt signaling pathway, p-AKT (phosphorylated Akt) participates in the process of oxidative stress and plays a prognostic role in various hematologic tumors and solid tumors.

We examined how concentrations of key metabolites and signaling pathways interact to maintain homeostasis in proliferating human cells, using fluorescent reporters for AMPK activity, Akt activity, and ...