Consistent with previously published work suggesting that S6K is the principal downstream signal affected ... 6 and also the trial of an AKT inhibitor in which a patient with metastatic pancreatic ...

pS6 positive cells encompassed also T, B and dendritic cells (DCs) and AKT activation (figure 1I). These data suggest that PI3Kδ is engaged in several cell types within pSS inflammatory infiltrates ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

Rather than the PI3K/AKT pathway mediating single unidirectional ... downregulation of phosphorylation of proteins, including p70 S6K, and functionally in terms of cell proliferation.

RB759 akt-1 (ok525)V., VC204 akt-2 (ok393 ... signaling pathway as well as mTOR and its downstream effector S6K, which play pivotal roles in numerous life extension interventions (Na. et al., 2017).

The deficiency of these nutrients upregulates Wingless in a closely located tissue, body wall muscle. Muscle-derived Wingless activates Akt in the neurons through the receptor tyrosine kinase Ror, ...

We examined how concentrations of key metabolites and signaling pathways interact to maintain homeostasis in proliferating human cells, using fluorescent reporters for AMPK activity, Akt activity, and ...

The results showed that exposure to NE led to not only an increased autophagy in cultured granulosa cells but also a decreased activation of AKT and S6K I, the pathways that are known to regulate ...