Slow transport via folate receptor (lower affinity for methotrexate than for folic acid) Increased drug efflux via ATP-binding cassette (ABC) subfamily transporters ABCC1–ABCC5 and ABCG2 ...
ABSTRACT: Rabson-Mendenhall syndrome (RMS) is a rare autosomal recessive inherited disease marked by insulin resistance. Mutations in the insulin receptor gene seem to be the fundamental mechanism ...