Although it mediates p53-driven repression through the canonical p53-p21-Rb axis, the potential for p53 to directly regulate DREAM targets independently of its transcriptional activity has not been ...

Results: Our research showed that DHIE and breast cancer enriched core gene targets mainly act on epithelial cells in breast cancer tissues and significantly inhibit the growth of breast cancer by ...

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

VERDICT With its well-appointed interior and fun-yet-refined driving manners, the Mazda 3 is a mainstream compact with high aspirations. As one of our favorites in its segment, the Mazda 3 has ...

Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cancer cases annually. Here we present a thermodynamic model that quantifies and links the major pathways by which ...

Colorectal cancer (CRC) is ranked as the third most commonly diagnosed cancer type after the lung and breast cancers worldwide beyond its geographical variations and localized temporal trends (1). The ...

About half of all cancers in humans have a mutation in one of the two copies of a tumor suppressor gene that encodes a protein called p53, which helps to control how and when cells grow and divide. In ...