VERZENIO's Market Potential Soars as Demand for CDK4/6 Inhibitors Grows | DelveInsight
DelveInsight's "VERZENIO Market Size, Forecast, and Market Insight Report" highlights the details around VERZENIO, which is a ...
Precision Medicine Online15d
Alterome Therapeutics Begins Phase I Trial of ALTA3263 in KRAS-Mutant Solid Tumors
NEW YORK – Alterome Therapeutics said on Monday it has started treating patients with KRAS-mutant advanced solid tumors with its KRAS inhibitor ALTA3263 in a Phase I trial.
icr.ac.uk21d
Genetic factors likely to determine which patients will benefit from new prostate cancer combination therapy
The researchers also investigated the PIK3CA/AKT1/PTEN pathway, which is known to be a major signalling pathway in multiple types of cancer. It has roles in controlling the survival and spread of ...
BioWorld28d
Terremoto Biosciences patents AKT1 inhibitors for cancer
Terremoto Biosciences patents AKT1 inhibitors for cancer Feb. 26, 2025 Terremoto Biosciences Inc. has synthesized new 3 H -imidazo[4,5- b ]pyridine compounds acting as RAC-α serine/threonine-protein ...
Frontiers28d
Gentiopicroside targeting AKT1 activates HIF-1α/VEGF axis promoting diabetic ulcer wound healing
Result: A total of 538 targets of GSP and 10795 DU-related targets were predicted; Venn analysis identified 215 potential targets for GSP to accelerate DU wound healing; PPI network analysis suggested ...
Frontiers29d
Effect of the CSFV NS5A protein on key proteins in the MAPK and PI3K-mTOR signaling pathways in porcine macrophages
The results revealed that with increasing infection time, the expression of IKBKG, AKT1, CDC37, MAP3K2, and PKN2 decreased, whereas the expression of MAP3K7 and KRAS2 increased. The 3D4/21 cells ...
eLife7y
Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis
SCP1 as a nuclear transcriptional regulator acts globally to silence neuronal genes and to affect the dephosphorylation of RNA Pol ll. However, we report the first finding and description of SCP1 as a ...
eLife8y
Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration
Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, ...