Plasma membrane cholesterol accumulation affects α 1-AR signaling and promotes loss of SMC contractile markers in vitro. ABCA1 and ABCG1 (ATP-binding cassette transporter A1 and G1) mediate ...

The researchers focused on ABCA1, a protein that aids in producing high-density lipoprotein (HDL) cholesterol, often referred to as “good” cholesterol. In healthy brains, HDL supports cell ...

Scientists discovered that elevated oxysterol traps ABCA1 in lysosomes, disrupting cholesterol metabolism and increasing Alzheimer’s risk. Lowering oxysterol restored ABCA1 function and reduced ...

The study, the culmination of a decade of research on a protein known as ATP-binding cassette transporter A1 (ABCA1), was just published in the journal Molecular Neurodegeneration. Past research ...

To study the mechanism through which this happens, the researchers knocked out the astrocyte gene that codes for ABCA1, a protein that aids the movement of cholesterol in the brain, then cultured the ...