The record comes in a season in which the White Sox had multiple double-digit losing streaks and fired manager Pedro Grifol.

The Chicago White Sox now have the dubious distinction of having lost the most games in a modern Major League Baseball season ...

The Chicago White Sox lost their post-1900s, major league-record 121st game Friday night, falling 4-1 to the Detroit Tigers ...

Again, on Wednesday, the White Sox avoided setting the record. Andrew Benintendi walked off the game ... who also rank high ...

The Chicago White Sox have set the record nobody want to make - they lost their 121st game of the season, the most ever in a ...

After listening all week to Chicago White Sox general manager Chris Getz, manager Grady Sizemore and players discussing their ...

The Chicago White Sox's social media team continues to set a standard the players have failed to match on the field. A day after the White Sox suffered ...

While the Detroit Tigers were celebrating their 4-1 win over the Chicago White Sox that clinched the team's first playoff berth since 2014 on Friday ...

With a 4-1 loss to the Detroit Tigers, the White Sox fell to 39-121. They now hold sole possession of the MLB record for ...

The White Sox fired manager Pedro Grifol on Aug. 8 soon after the 21-game losing streak. Interim manager Grady Sizemore is ...

The Chicago White Sox suffered loss No. 121 of the season Friday, breaking the modern-day Major League Baseball record.

The White Sox hit "the wrong side of history" with Friday night's 4-1 loss to the Tigers, breaking the MLB record with their ...