Polyglutamine (polyQ) diseases, a group of dominantly inherited CNS disorders, are caused by an abnormal expansion of ...

Optimal therapeutic targeting of cancer involves clonal signals which are expressed within all cancer cellsGradalis applies a novel clinically ...

The National Testing Agency (NTA) is set to announce the dates for the Joint Entrance Examination (JEE) Main 2025 in the coming days. Aspiring candidates can check the official schedule once it's ...

Preclinical data with the investigational gene therapy INS1202 show improvements in survival and motor performance in ALS.

The stably transfected CaCO 2 cell line was treated with puromycin (4 μg/mL) for 14 days for selection. The sequence of shRNA is GCC CAC TGT TAT CTT CAC TTT. In this study, we extracted total RNA ...

To generate tumour cell lines stably expressing short hairpin STAT3, KP2 cells were transduced with lentivirus particles carrying short hairpin RNA (shRNA) for 48 hours, following standard ...

(I) The pulmonary metastatic nodules were stained using H&E staining and counted in nude mice harboring NCI-H1299 cells transfected with PDE1A shRNA and control shRNA. Figure 3: PDE1A promotes the ...

BACKGROUND: Morbidity and mortality of heart failure with preserved ejection fraction (HFpEF) is increased in metabolic disorders. However, options for preventing and treating these prevalent outcomes ...

The global oligonucleotide API market is poised to grow from USD 2.81 billion in 2024 to USD 4.84 billion by 2034, expanding at a CAGR of 5.60%. The increasing need for innovative drug classes and ...