Frontiers17d
Research progress on AMPK in the pathogenesis and treatment of MASLD
Additionally, AMPK promotes lipid breakdown through regulation of lipophagy, specifically by (1): Direct phosphorylation of ULK1 to initiate autophagosome formation (2); Inhibition of mTORC1 through ...
BioWorld8d
Shenzhen Zhongge Biotechnology divulges new ULK1 inhibitors
Shenzhen Zhongge Biotechnology Co. Ltd. has synthesized serine/threonine-protein kinase ULK1 inhibitors reported to be useful for the treatment of cancer, lymphangioleiomyomatosis and tuberous ...
eLife28d
Small-molecule Activation of TFEB Alleviates Niemann-Pick Disease Type C via Promoting Lysosomal Exocytosis and Biogenesis
This study reports that activation of TFEB promotes lysosomal exocytosis and clearance of cholesterol from lysosomes, the strength of evidence for which is convincing with appropriate and validated ...
SciELO6d
circLOC375190 promotes autophagy through modulation of the mTORC1/TFEB axis in acute ischemic stroke-induced neurological injury
circLOC375190 affects AIS autophagy by regulating the mTORC1/TFEB axis. Therefore, to provide a theoretical foundation for the treatment of AIS, the authors explored the specific mechanism of ...
Frontiers23d
Autophagy and Skin Diseases
Autophagy is controlled by a variety of growth and nutrition signaling pathways. mTORC1 activity, which reflects cellular nutritional status, is a major regulator of autophagy. Since the ULK complex ...
The EMBO Journal22d
Phosphatidylinositol 3‐phosphates—at the interface between cell signalling and membrane traffic
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