Comparison of laparoscopic radiofrequency ablation with percutaneous radiofrequency ablation in the treatment of chronic hepatitis B-related hepatocellular carcinoma involving specific sites: A ...
Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...
Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education, Hebei Key Laboratory of Forensic Medicine ...
In NPC1 cells, SFN induces TFEB nuclear translocation via a ROS-Ca 2+-calcineurin dependent but MTOR-independent pathway and upregulates the expression of TFEB-downstream genes, promoting lysosomal ...
Chair of Proteomics and Bioanalytics, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany Chair of Proteomics and Bioanalytics, School of Life Sciences, Technical ...
Background Gastric Cancer (GC) was the third highest mortality rate among malignant tumors. Currently, no specific treatment is utilized to prevent the progression of GC. The detailed mechanism of GC ...
The implications of the therapeutic paradigm shift toward editing of HL tissue, and particularly mTOR addiction, could prove to be profound for clinical practice, both in terms of outcome and ...
mTOR, Mechanistic Target Of Rapamycin; STAT3, signal transducer and activator of transcription 3; TRPML1, transient receptor potential mucolipin 1; NO, nitric oxide; TME, tumor microenvironment; TAMs, ...
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