mTOR, Mechanistic Target Of Rapamycin; STAT3, signal transducer and activator of transcription 3; TRPML1, transient receptor potential mucolipin 1; NO, nitric oxide; TME, tumor microenvironment; TAMs, ...

Thus, novel, effective therapies are required for treatment of this disease. Results We found that tumours in KRAS PTEN mice exhibit a remarkable dependence on mTOR signalling. In these tumours, mTOR ...

Our drug discovery model has identified two novel STAT3 SH2 domain inhibitors 323–1 and 323–2 (delavatine A stereoisomers) in a series of experiments. In silico computational modeling, drug affinity ...

Objective To monitor trastuzumab resistance and determine the underlying mechanisms for the limited response rate and rapid emergence of resistance of HER2+ metastatic gastric cancer (mGC). Design ...