Therefore, rapamycin appears to be exerting its antitumour effects though S6K, and thus, pS6 may be the best marker for measuring response to mTOR inhibitors ... a dramatic inhibition of ...

Samsung‘s Galaxy S series made its debut on June 4, 2010, and since then it’s become the phone line most people think of when Android is mentioned. Not all phones are created equal though, so ...

The Galaxy Tab S6 Lite is a new addition to Samsung's tablet lineup. As its name suggests, this is a less expensive version of the Samsung Galaxy Tab S6, which I reviewed late last year. The Galaxy ...

This valuable study identifies a protein called adenosine deaminase-related growth factor (ADGF) as a key regulator of tip formation in the slime mold Dictyostelium discoideum. The authors ...

Roughly six months ago, the company launched the Galaxy S6 and Galaxy S6 Edge, which were in such high demand that Samsung had trouble keeping up. To meet the voracious appetite of consumers, Samsung ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. m 6 A RNA modification has been linked to ...

Results Rapamycin affected the mTOR signalling pathway in mouse knee joints as indicated by the inhibition of ribosomal protein S6 phosphorylation, a target of mTOR and activation of LC3, a main ...

Objective The authors explored differentially expressed circRNAs in Acute Ischemic Stroke (AIS) and revealed the role and potential downstream molecular mechanisms of circLOC375190. Methods ...

The implications of the therapeutic paradigm shift toward editing of HL tissue, and particularly mTOR addiction, could prove to be profound for clinical practice, both in terms of outcome and ...

Methods and results Target validation assays showed significant expression of phosphorylated ribosomal protein S6 (pS6), a downstream mediator of the phosphatidylinositol 3-kinase delta (PI3Kδ) ...