The latest premiere of the longest-running US medical drama was dedicated to Stephanie Leifer and, while casual fans of the long-running medical drama might not be aware of who she is, the tribute was a moving moment as Leifer was an instrumental figure in the show’s enduring success.

Last season, Grey’s Anatomy aired at 9/8c after brand-new episodes of 9-1-1. For Season 21, ABC implemented a dramatic schedule change for Meredith Grey & Co. Grey’s Anatomy Season 21 will premiere on Thursday, September 26, at 10/9c, an hour later than last season. The 18-episode season will stay at that timeslot.

The Season 21 premiere of "Grey's Anatomy" will air on ABC. Fans can also stream the episode on Hulu Friday morning. The first 20 seasons of the series are available to stream on both Netflix and Hulu. Netflix typically adds new seasons of "Grey's Anatomy" after a season wraps up and the same is expected for Season 21.