In a major breakthrough for rhodesiense human African trypanosomiasis (r-HAT) treatment, in August 2024 WHO recommended fexinidazole to replace ...

Bernhard et al. reveal the architecture of the tetrameric Trypanosoma brucei nuclear cap-binding complex. Using cryo-electron microscopy and biochemical assays, the researchers characterize its ...

Origin firing is the initiation of DNA replication that takes place at specialised start sites, or replication origins, where the DNA first has to be opened up and unwound, before DNA synthesis ...